Right ventricle free wall mechanics in metabolic syndrome without type-2 diabetes: effects of a 3-month lifestyle intervention program
Identifieur interne : 003538 ( Main/Exploration ); précédent : 003537; suivant : 003539Right ventricle free wall mechanics in metabolic syndrome without type-2 diabetes: effects of a 3-month lifestyle intervention program
Auteurs : Juan Serrano-Ferrer [France] ; Guillaume Walther [France, Australie] ; Edward Crendal [France, Australie] ; Agnès Vinet [France] ; Frédéric Dutheil [Australie, France] ; Geraldine Naughton [Australie] ; Bruno Lesourd [France] ; Robert Chapier [France] ; Daniel Courteix [Australie, France] ; Philippe Obert [France, Australie]Source :
- Cardiovascular Diabetology [ 1475-2840 ] ; 2014.
Abstract
Growing evidence demonstrates subtle left ventricular myocardial dysfunction in patients with metabolic syndrome (MetS), with central obesity, glucose intolerance and inflammation emerging as important contributors. Whether these results can be translated to the right ventricle (RV) is not yet fully elucidated. Furthermore, although lifestyle intervention favorably impacts MetS components and inflammatory biomarkers, its effect on RV myocardial function remains unknown today.
Thirty-nine MetS adults free of diabetes were enrolled in a three month lifestyle intervention program including diet and physical exercise, and compared with forty healthy controls. Blood biochemistry, echocardiography including tissue Doppler imaging (TDI), and vector velocity imaging of the RV free wall to assess global longitudinal strain (GLS) and strain rates (SR) were obtained at baseline and after the intervention.
Compared with controls, MetS patients presented similar right atrial and RV morphology but reduced systolic (P = 0.04) and early diastolic (P = 0.02) velocities of the tricuspid annulus. They showed attenuated RV GLS (−21.4 ± 4.5vs-25.7 ± 4.9%, P < 0.001) as well as early diastolic (P = 0.003) and systolic (P < 0.001) SR. Multiple regression analyses revealed log PAI-1 active, (P < 0.001), log adiponectin, (P = 0.01), LV mass indexed (P = 0.004) and central fat (P = 0.03) as independent predictors of RV GLS (R2 = 0.46, P < 0.001). Biological markers of MetS and inflammation as well as RV GLS (−21.8 ± 3.8vs-24.3 ± 3.0%, P = 0.009) and systolic (P = 0.003) and early diastolic (P = 0.01) SR, but not TDI indexes, significantly improved after diet and exercise training, and vector velocity imaging data in MetS following the lifestyle intervention no longer differed from controls.
MetS is associated with subtle impairments in both RV free wall diastolic and systolic myocardial function which could be partly related to central-obesity induced changes in pro- and anti-inflammatory cytokines and left ventricular remodeling. The favorable impact of healthy dieting and physical activity on RV free wall mechanics indicates that cellular and sub-cellular alterations responsible for the RV myocardial abnormalities are probably not permanent and modifiable throughout adequate interventional strategies.
American National Institutes of Health database
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DOI: 10.1186/s12933-014-0116-9
PubMed: 25407698
PubMed Central: 4149206
Affiliations:
- Australie, France
- Auvergne (région administrative), Auvergne-Rhône-Alpes, Provence-Alpes-Côte d'Azur, Victoria (État)
- Avignon, Clermont-Ferrand, Melbourne
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diabetes: effects of a 3-month lifestyle intervention program</title><author><name sortKey="Serrano Ferrer, Juan" sort="Serrano Ferrer, Juan" uniqKey="Serrano Ferrer J" first="Juan" last="Serrano-Ferrer">Juan Serrano-Ferrer</name><affiliation wicri:level="3"><nlm:aff id="I1">Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Avignon</settlement></placeName></affiliation></author><author><name sortKey="Walther, Guillaume" sort="Walther, Guillaume" uniqKey="Walther G" first="Guillaume" last="Walther">Guillaume Walther</name><affiliation wicri:level="3"><nlm:aff id="I1">Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Avignon</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I2">Australian Catholic University, School of Exercise Science, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Catholic University, School of Exercise Science, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Crendal, Edward" sort="Crendal, Edward" uniqKey="Crendal E" first="Edward" last="Crendal">Edward Crendal</name><affiliation wicri:level="3"><nlm:aff id="I1">Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Avignon</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I2">Australian Catholic University, School of Exercise Science, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Catholic University, School of Exercise Science, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Vinet, Agnes" sort="Vinet, Agnes" uniqKey="Vinet A" first="Agnès" last="Vinet">Agnès Vinet</name><affiliation wicri:level="3"><nlm:aff id="I1">Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Avignon</settlement></placeName></affiliation></author><author><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Frédéric" last="Dutheil">Frédéric Dutheil</name><affiliation wicri:level="3"><nlm:aff id="I2">Australian Catholic University, School of Exercise Science, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Catholic University, School of Exercise Science, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions (AME2P), Clermont-Ferrand, EA3533, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions (AME2P), Clermont-Ferrand, EA3533</wicri:regionArea><wicri:noRegion>EA3533</wicri:noRegion><wicri:noRegion>EA3533</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="I4">University Hospital of Clermont-Ferrand CHU, Clermont-Ferrand, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Hospital of Clermont-Ferrand CHU, Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Naughton, Geraldine" sort="Naughton, Geraldine" uniqKey="Naughton G" first="Geraldine" last="Naughton">Geraldine Naughton</name><affiliation wicri:level="3"><nlm:aff id="I2">Australian Catholic University, School of Exercise Science, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Catholic University, School of Exercise Science, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Lesourd, Bruno" sort="Lesourd, Bruno" uniqKey="Lesourd B" first="Bruno" last="Lesourd">Bruno Lesourd</name><affiliation wicri:level="1"><nlm:aff id="I3">Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions (AME2P), Clermont-Ferrand, EA3533, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions (AME2P), Clermont-Ferrand, EA3533</wicri:regionArea><wicri:noRegion>EA3533</wicri:noRegion><wicri:noRegion>EA3533</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="I4">University Hospital of Clermont-Ferrand CHU, Clermont-Ferrand, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Hospital of Clermont-Ferrand CHU, Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Chapier, Robert" sort="Chapier, Robert" uniqKey="Chapier R" first="Robert" last="Chapier">Robert Chapier</name><affiliation wicri:level="1"><nlm:aff id="I5">Omental – Thermalia Center, Châtelguyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Omental – Thermalia Center, Châtelguyon</wicri:regionArea><wicri:noRegion>Châtelguyon</wicri:noRegion><wicri:noRegion>Châtelguyon</wicri:noRegion></affiliation></author><author><name sortKey="Courteix, Daniel" sort="Courteix, Daniel" uniqKey="Courteix D" first="Daniel" last="Courteix">Daniel Courteix</name><affiliation wicri:level="3"><nlm:aff id="I2">Australian Catholic University, School of Exercise Science, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Catholic University, School of Exercise Science, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions (AME2P), Clermont-Ferrand, EA3533, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions (AME2P), Clermont-Ferrand, EA3533</wicri:regionArea><wicri:noRegion>EA3533</wicri:noRegion><wicri:noRegion>EA3533</wicri:noRegion></affiliation></author><author><name sortKey="Obert, Philippe" sort="Obert, Philippe" uniqKey="Obert P" first="Philippe" last="Obert">Philippe Obert</name><affiliation wicri:level="3"><nlm:aff id="I1">Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Avignon University, Laboratoire de Pharm-Ecologie cardiovasculaire, LAPEC EA4278, Avignon</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Avignon</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I2">Australian Catholic University, School of Exercise Science, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Catholic University, School of Exercise Science, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></analytic><series><title level="j">Cardiovascular Diabetology</title><idno type="eISSN">1475-2840</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Growing evidence demonstrates subtle left ventricular myocardial dysfunction in patients with metabolic syndrome (MetS), with central obesity, glucose intolerance and inflammation emerging as important contributors. Whether these results can be translated to the right ventricle (RV) is not yet fully elucidated. Furthermore, although lifestyle intervention favorably impacts MetS components and inflammatory biomarkers, its effect on RV myocardial function remains unknown today.</p></sec><sec><title>Methods</title><p>Thirty-nine MetS adults free of diabetes were enrolled in a three month lifestyle intervention program including diet and physical exercise, and compared with forty healthy controls. Blood biochemistry, echocardiography including tissue Doppler imaging (TDI), and vector velocity imaging of the RV free wall to assess global longitudinal strain (GLS) and strain rates (SR) were obtained at baseline and after the intervention.</p></sec><sec><title>Results</title><p>Compared with controls, MetS patients presented similar right atrial and RV morphology but reduced systolic (P = 0.04) and early diastolic (P = 0.02) velocities of the tricuspid annulus. They showed attenuated RV GLS (−21.4 ± 4.5vs-25.7 ± 4.9%, P < 0.001) as well as early diastolic (P = 0.003) and systolic (P < 0.001) SR. Multiple regression analyses revealed log PAI-1 active, (P < 0.001), log adiponectin, (P = 0.01), LV mass indexed (P = 0.004) and central fat (P = 0.03) as independent predictors of RV GLS (R<sup>2</sup> = 0.46, P < 0.001). Biological markers of MetS and inflammation as well as RV GLS (−21.8 ± 3.8vs-24.3 ± 3.0%, P = 0.009) and systolic (P = 0.003) and early diastolic (P = 0.01) SR, but not TDI indexes, significantly improved after diet and exercise training, and vector velocity imaging data in MetS following the lifestyle intervention no longer differed from controls.</p></sec><sec><title>Conclusions</title><p>MetS is associated with subtle impairments in both RV free wall diastolic and systolic myocardial function which could be partly related to central-obesity induced changes in pro- and anti-inflammatory cytokines and left ventricular remodeling. The favorable impact of healthy dieting and physical activity on RV free wall mechanics indicates that cellular and sub-cellular alterations responsible for the RV myocardial abnormalities are probably not permanent and modifiable throughout adequate interventional strategies.</p></sec><sec><title>Trial registration</title><p>American National Institutes of Health database <ext-link ext-link-type="uri" xlink:href="NCT00917917">NCT00917917</ext-link>.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mottillo, S" uniqKey="Mottillo S">S Mottillo</name></author><author><name sortKey="Filion, Kb" uniqKey="Filion K">KB Filion</name></author><author><name sortKey="Genest, J" uniqKey="Genest J">J Genest</name></author><author><name sortKey="Joseph, L" uniqKey="Joseph L">L Joseph</name></author><author><name sortKey="Pilote, L" uniqKey="Pilote L">L Pilote</name></author><author><name sortKey="Poirier, P" uniqKey="Poirier P">P Poirier</name></author><author><name sortKey="Rinfret, S" uniqKey="Rinfret S">S Rinfret</name></author><author><name sortKey="Schiffrin, E" uniqKey="Schiffrin E">E Schiffrin</name></author><author><name sortKey="Eisenberg, M" uniqKey="Eisenberg M">M Eisenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eckel, Rh" uniqKey="Eckel R">RH Eckel</name></author><author><name sortKey="Grundy, Sm" uniqKey="Grundy S">SM Grundy</name></author><author><name sortKey="Zimmet, Pz" uniqKey="Zimmet P">PZ Zimmet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crendal, E" uniqKey="Crendal E">E Crendal</name></author><author><name sortKey="Walther, G" uniqKey="Walther G">G Walther</name></author><author><name sortKey="Vinet, A" uniqKey="Vinet A">A Vinet</name></author><author><name sortKey="Dutheil, F" uniqKey="Dutheil F">F Dutheil</name></author><author><name sortKey="Naughton, G" uniqKey="Naughton G">G Naughton</name></author><author><name sortKey="Lesourd, B" uniqKey="Lesourd B">B Lesourd</name></author><author><name sortKey="Chapier, R" uniqKey="Chapier R">R Chapier</name></author><author><name sortKey="Rupp, T" uniqKey="Rupp T">T Rupp</name></author><author><name sortKey="Courteix, D" uniqKey="Courteix D">D Courteix</name></author><author><name sortKey="Obert, P" uniqKey="Obert P">P Obert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Azevedo, A" uniqKey="Azevedo A">A Azevedo</name></author><author><name sortKey="Bettencourt, P" uniqKey="Bettencourt P">P Bettencourt</name></author><author><name sortKey="Almeida, Pb" uniqKey="Almeida P">PB Almeida</name></author><author><name sortKey="Santos, Ac" uniqKey="Santos A">AC Santos</name></author><author><name sortKey="Abreu Lima, C" uniqKey="Abreu Lima C">C Abreu-Lima</name></author><author><name sortKey="Hense, Hw" uniqKey="Hense H">HW Hense</name></author><author><name sortKey="Barros, H" uniqKey="Barros H">H Barros</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dandel, M" uniqKey="Dandel M">M Dandel</name></author><author><name sortKey="Lehmkuhl, H" uniqKey="Lehmkuhl H">H Lehmkuhl</name></author><author><name sortKey="Knosalla, C" uniqKey="Knosalla C">C Knosalla</name></author><author><name sortKey="Suramelashvili, N" uniqKey="Suramelashvili N">N Suramelashvili</name></author><author><name sortKey="Hetzer, R" uniqKey="Hetzer R">R Hetzer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mor Avi, V" uniqKey="Mor Avi V">V Mor-Avi</name></author><author><name sortKey="Lang, Rm" uniqKey="Lang R">RM Lang</name></author><author><name sortKey="Badano, Lp" uniqKey="Badano L">LP Badano</name></author><author><name sortKey="Belohlavek, M" uniqKey="Belohlavek M">M Belohlavek</name></author><author><name sortKey="Cardim, Nm" uniqKey="Cardim N">NM Cardim</name></author><author><name sortKey="Derumeaux, G" uniqKey="Derumeaux G">G Derumeaux</name></author><author><name sortKey="Cardim, Nm" uniqKey="Cardim N">NM Cardim</name></author><author><name sortKey="Derumeaux, G" uniqKey="Derumeaux G">G Derumeaux</name></author><author><name sortKey="Galderisi, M" uniqKey="Galderisi M">M Galderisi</name></author><author><name sortKey="Marwick, T" uniqKey="Marwick T">T Marwick</name></author><author><name sortKey="Nagueh, Sf" uniqKey="Nagueh S">SF Nagueh</name></author><author><name sortKey="Sengupta, Pp" uniqKey="Sengupta P">PP Sengupta</name></author><author><name sortKey="Sicari, R" uniqKey="Sicari R">R Sicari</name></author><author><name sortKey="Smiseth, Oa" uniqKey="Smiseth O">OA Smiseth</name></author><author><name sortKey="Smulevitz, B" uniqKey="Smulevitz B">B Smulevitz</name></author><author><name sortKey="Takeuchi, M" uniqKey="Takeuchi M">M Takeuchi</name></author><author><name sortKey="Thomas, Jd" uniqKey="Thomas J">JD Thomas</name></author><author><name sortKey="Vannan, M" uniqKey="Vannan M">M Vannan</name></author><author><name sortKey="Voigt, Ju" uniqKey="Voigt J">JU Voigt</name></author><author><name sortKey="Zamorano, Jl" uniqKey="Zamorano J">JL Zamorano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gong, H" uniqKey="Gong H">H Gong</name></author><author><name sortKey="Tan, H" uniqKey="Tan H">H Tan</name></author><author><name sortKey="Fang, N" uniqKey="Fang N">N Fang</name></author><author><name sortKey="Song, T" uniqKey="Song T">T Song</name></author><author><name sortKey="Li, S" uniqKey="Li S">S Li</name></author><author><name sortKey="Zhong, M" uniqKey="Zhong M">M Zhong</name></author><author><name sortKey="Zhong, M" uniqKey="Zhong M">M Zhong</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seo, J M" uniqKey="Seo J">J-M Seo</name></author><author><name sortKey="Park, T H" uniqKey="Park T">T-H Park</name></author><author><name sortKey="Lee, D Y" uniqKey="Lee D">D-Y Lee</name></author><author><name sortKey="Cho, Yr" uniqKey="Cho Y">YR Cho</name></author><author><name sortKey="Baek, Hk" uniqKey="Baek H">HK Baek</name></author><author><name sortKey="Park, Js" uniqKey="Park J">JS Park</name></author><author><name sortKey="Kim, Mh" uniqKey="Kim M">MH Kim</name></author><author><name sortKey="Kim, Yd" uniqKey="Kim Y">YD Kim</name></author><author><name sortKey="Choi, Sy" uniqKey="Choi S">SY Choi</name></author><author><name sortKey="Lee, Sm" uniqKey="Lee S">SM Lee</name></author><author><name sortKey="Hong, Ys" uniqKey="Hong Y">YS Hong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tadic, M" uniqKey="Tadic M">M Tadic</name></author><author><name sortKey="Ivanovic, B" uniqKey="Ivanovic B">B Ivanovic</name></author><author><name sortKey="Grozdic, I" uniqKey="Grozdic I">I Grozdic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paneni, F" uniqKey="Paneni F">F Paneni</name></author><author><name sortKey="Gregori, M" uniqKey="Gregori M">M Gregori</name></author><author><name sortKey="Tocci, G" uniqKey="Tocci G">G Tocci</name></author><author><name sortKey="Palano, F" uniqKey="Palano F">F Palano</name></author><author><name sortKey="Ciavarella, Gm" uniqKey="Ciavarella G">GM Ciavarella</name></author><author><name sortKey="Pignatelli, G" uniqKey="Pignatelli G">G Pignatelli</name></author><author><name sortKey="Marra, A" uniqKey="Marra A">A Marra</name></author><author><name sortKey="Sciarretta, S" uniqKey="Sciarretta S">S Sciarretta</name></author><author><name sortKey="Ferrucci, A" uniqKey="Ferrucci A">A Ferrucci</name></author><author><name sortKey="Volpe, M" uniqKey="Volpe M">M Volpe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karakurt, O" uniqKey="Karakurt O">O Karakurt</name></author><author><name sortKey="Oztekin, S" uniqKey="Oztekin S">S Oztekin</name></author><author><name sortKey="Yaz Han, N" uniqKey="Yaz Han N">N Yazıhan</name></author><author><name sortKey="Akdemir, R" uniqKey="Akdemir R">R Akdemir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gokdeniz, T" uniqKey="Gokdeniz T">T Gökdeniz</name></author><author><name sortKey="Erkol, A" uniqKey="Erkol A">A Erkol</name></author><author><name sortKey="Kalayc O Lu, E" uniqKey="Kalayc O Lu E">E Kalaycıoğlu</name></author><author><name sortKey="Ca R Aykan, A" uniqKey="Ca R Aykan A">A Cağrı Aykan</name></author><author><name sortKey="Gul, I" uniqKey="Gul I">I Gül</name></author><author><name sortKey="Boyac, F" uniqKey="Boyac F">F Boyacı</name></author><author><name sortKey="Turan, B" uniqKey="Turan B">B Turan</name></author><author><name sortKey="Ozkan, M" uniqKey="Ozkan M">M Ozkan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kosmala, W" uniqKey="Kosmala W">W Kosmala</name></author><author><name sortKey="Przewlocka Kosmala, M" uniqKey="Przewlocka Kosmala M">M Przewlocka-Kosmala</name></author><author><name sortKey="Mazurek, W" uniqKey="Mazurek W">W Mazurek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parsaee, M" uniqKey="Parsaee M">M Parsaee</name></author><author><name sortKey="Bahmanziari, P" uniqKey="Bahmanziari P">P Bahmanziari</name></author><author><name sortKey="Ardeshiri, M" uniqKey="Ardeshiri M">M Ardeshiri</name></author><author><name sortKey="Esmaeilzadeh, M" uniqKey="Esmaeilzadeh M">M Esmaeilzadeh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vittos, O" uniqKey="Vittos O">O Vittos</name></author><author><name sortKey="Toana, B" uniqKey="Toana B">B Toana</name></author><author><name sortKey="Vittos, A" uniqKey="Vittos A">A Vittos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tadic, M" uniqKey="Tadic M">M Tadic</name></author><author><name sortKey="Ivanovic, B" uniqKey="Ivanovic B">B Ivanovic</name></author><author><name sortKey="Cuspidi, C" uniqKey="Cuspidi C">C Cuspidi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, Ct" uniqKey="Zhao C">CT Zhao</name></author><author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name></author><author><name sortKey="Siu, Cw" uniqKey="Siu C">CW Siu</name></author><author><name sortKey="Hou, Yl" uniqKey="Hou Y">YL Hou</name></author><author><name sortKey="Wang, T" uniqKey="Wang T">T Wang</name></author><author><name sortKey="Tse, Hf" uniqKey="Tse H">HF Tse</name></author><author><name sortKey="Yiu, Kh" uniqKey="Yiu K">KH Yiu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Wei, X" uniqKey="Wei X">X Wei</name></author><author><name sortKey="Liang, Y" uniqKey="Liang Y">Y Liang</name></author><author><name sortKey="Liu, M" uniqKey="Liu M">M Liu</name></author><author><name sortKey="Li, C" uniqKey="Li C">C Li</name></author><author><name sortKey="Tang, H" uniqKey="Tang H">H Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pop Busui, R" uniqKey="Pop Busui R">R Pop-Busui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tadic, M" uniqKey="Tadic M">M Tadic</name></author><author><name sortKey="Cuspidi, C" uniqKey="Cuspidi C">C Cuspidi</name></author><author><name sortKey="Sljivic, A" uniqKey="Sljivic A">A Sljivic</name></author><author><name sortKey="Andric, A" uniqKey="Andric A">A Andric</name></author><author><name sortKey="Ivanovic, B" uniqKey="Ivanovic B">B Ivanovic</name></author><author><name sortKey="Scepanovic, R" uniqKey="Scepanovic R">R Scepanovic</name></author><author><name sortKey="Ilic, I" uniqKey="Ilic I">I Ilic</name></author><author><name sortKey="Jozika, L" uniqKey="Jozika L">L Jozika</name></author><author><name sortKey="Marjanovic, T" uniqKey="Marjanovic T">T Marjanovic</name></author><author><name sortKey="Celic, V" uniqKey="Celic V">V Celic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hansen, D" uniqKey="Hansen D">D Hansen</name></author><author><name sortKey="Dendale, P" uniqKey="Dendale P">P Dendale</name></author><author><name sortKey="Van Loon, Ljc" uniqKey="Van Loon L">LJC van Loon</name></author><author><name sortKey="Meeusen, R" uniqKey="Meeusen R">R Meeusen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vissers, D" uniqKey="Vissers D">D Vissers</name></author><author><name sortKey="Hens, W" uniqKey="Hens W">W Hens</name></author><author><name sortKey="Taeymans, J" uniqKey="Taeymans J">J Taeymans</name></author><author><name sortKey="Baeyens, J P" uniqKey="Baeyens J">J-P Baeyens</name></author><author><name sortKey="Poortmans, J" uniqKey="Poortmans J">J Poortmans</name></author><author><name sortKey="Van Gaal, L" uniqKey="Van Gaal L">L Van Gaal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ismail, I" uniqKey="Ismail I">I Ismail</name></author><author><name sortKey="Keating, Se" uniqKey="Keating S">SE Keating</name></author><author><name sortKey="Baker, Mk" uniqKey="Baker M">MK Baker</name></author><author><name sortKey="Johnson, Na" uniqKey="Johnson N">NA Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dutheil, F" uniqKey="Dutheil F">F Dutheil</name></author><author><name sortKey="Lac, G" uniqKey="Lac G">G Lac</name></author><author><name sortKey="Lesourd, B" uniqKey="Lesourd B">B Lesourd</name></author><author><name sortKey="Chapier, R" uniqKey="Chapier R">R Chapier</name></author><author><name sortKey="Walther, G" uniqKey="Walther G">G Walther</name></author><author><name sortKey="Vinet, A" uniqKey="Vinet A">A Vinet</name></author><author><name sortKey="Sapin, V" uniqKey="Sapin V">V Sapin</name></author><author><name sortKey="Verney, J" uniqKey="Verney J">J Verney</name></author><author><name sortKey="Ouchchane, L" uniqKey="Ouchchane L">L Ouchchane</name></author><author><name sortKey="Duclos, M" uniqKey="Duclos M">M Duclos</name></author><author><name sortKey="Obert, P" uniqKey="Obert P">P Obert</name></author><author><name sortKey="Courteix, D" uniqKey="Courteix D">D Courteix</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alberti, Kg" uniqKey="Alberti K">KG Alberti</name></author><author><name sortKey="Zimmet, P" uniqKey="Zimmet P">P Zimmet</name></author><author><name sortKey="Shaw, J" uniqKey="Shaw J">J Shaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rudski, Lg" uniqKey="Rudski L">LG Rudski</name></author><author><name sortKey="Lai, Ww" uniqKey="Lai W">WW Lai</name></author><author><name sortKey="Afilalo, J" uniqKey="Afilalo J">J Afilalo</name></author><author><name sortKey="Hua, L" uniqKey="Hua L">L Hua</name></author><author><name sortKey="Handschumacher, Md" uniqKey="Handschumacher M">MD Handschumacher</name></author><author><name sortKey="Chandrasekaran, K" uniqKey="Chandrasekaran K">K Chandrasekaran</name></author><author><name sortKey="Solomon, Sd" uniqKey="Solomon S">SD Solomon</name></author><author><name sortKey="Louie, Ek" uniqKey="Louie E">EK Louie</name></author><author><name sortKey="Schiller, Nb" uniqKey="Schiller N">NB Schiller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galie, N" uniqKey="Galie N">N Galiè</name></author><author><name sortKey="Hoeper, Mm" uniqKey="Hoeper M">MM Hoeper</name></author><author><name sortKey="Humbert, M" uniqKey="Humbert M">M Humbert</name></author><author><name sortKey="Torbicki, A" uniqKey="Torbicki A">A Torbicki</name></author><author><name sortKey="Vachiery, Jl" uniqKey="Vachiery J">JL Vachiery</name></author><author><name sortKey="Barbera, Ja" uniqKey="Barbera J">JA Barbera</name></author><author><name sortKey="Beghetti, M" uniqKey="Beghetti M">M Beghetti</name></author><author><name sortKey="Corris, P" uniqKey="Corris P">P Corris</name></author><author><name sortKey="Gaine, S" uniqKey="Gaine S">S Gaine</name></author><author><name sortKey="Gibbs, Js" uniqKey="Gibbs J">JS Gibbs</name></author><author><name sortKey="Gomez Sanchez, Ma" uniqKey="Gomez Sanchez M">MA Gomez-Sanchez</name></author><author><name sortKey="Jondeau, G" uniqKey="Jondeau G">G Jondeau</name></author><author><name sortKey="Klepetko, W" uniqKey="Klepetko W">W Klepetko</name></author><author><name sortKey="Opitz, C" uniqKey="Opitz C">C Opitz</name></author><author><name sortKey="Peacock, A" uniqKey="Peacock A">A Peacock</name></author><author><name sortKey="Rubin, L" uniqKey="Rubin L">L Rubin</name></author><author><name sortKey="Zellweger, M" uniqKey="Zellweger M">M Zellweger</name></author><author><name sortKey="Simonneau, G" uniqKey="Simonneau G">G Simonneau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matthews, Dr" uniqKey="Matthews D">DR Matthews</name></author><author><name sortKey="Hosker, Jp" uniqKey="Hosker J">JP Hosker</name></author><author><name sortKey="Rudenski, As" uniqKey="Rudenski A">AS Rudenski</name></author><author><name sortKey="Naylor, Ba" uniqKey="Naylor B">BA Naylor</name></author><author><name sortKey="Treacher, Df" uniqKey="Treacher D">DF Treacher</name></author><author><name sortKey="Turner, Rc" uniqKey="Turner R">RC Turner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagueh, Sf" uniqKey="Nagueh S">SF Nagueh</name></author><author><name sortKey="Appleton, Cp" uniqKey="Appleton C">CP Appleton</name></author><author><name sortKey="Gillebert, Tc" uniqKey="Gillebert T">TC Gillebert</name></author><author><name sortKey="Marino, Pn" uniqKey="Marino P">PN Marino</name></author><author><name sortKey="Oh, Jk" uniqKey="Oh J">JK Oh</name></author><author><name sortKey="Smiseth, Oa" uniqKey="Smiseth O">OA Smiseth</name></author><author><name sortKey="Smiseth, Oa" uniqKey="Smiseth O">OA Smiseth</name></author><author><name sortKey="Waggoner, Ad" uniqKey="Waggoner A">AD Waggoner</name></author><author><name sortKey="Flachskampf, Fa" uniqKey="Flachskampf F">FA Flachskampf</name></author><author><name sortKey="Pellikka, Pa" uniqKey="Pellikka P">PA Pellikka</name></author><author><name sortKey="Evangelisa, A" uniqKey="Evangelisa A">A Evangelisa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagueh, Sf" uniqKey="Nagueh S">SF Nagueh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagueh, Mf" uniqKey="Nagueh M">MF Nagueh</name></author><author><name sortKey="Kopelen, Ha" uniqKey="Kopelen H">HA Kopelen</name></author><author><name sortKey="Zoghbi, Wa" uniqKey="Zoghbi W">WA Zoghbi</name></author><author><name sortKey="Quinones, Ma" uniqKey="Quinones M">MA Quinones</name></author><author><name sortKey="Nagueh, Sf" uniqKey="Nagueh S">SF Nagueh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beigel, R" uniqKey="Beigel R">R Beigel</name></author><author><name sortKey="Cercek, B" uniqKey="Cercek B">B Cercek</name></author><author><name sortKey="Luo, H" uniqKey="Luo H">H Luo</name></author><author><name sortKey="Siegel, Rj" uniqKey="Siegel R">RJ Siegel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pirat, B" uniqKey="Pirat B">B Pirat</name></author><author><name sortKey="Khoury, Ds" uniqKey="Khoury D">DS Khoury</name></author><author><name sortKey="Hartley, Cj" uniqKey="Hartley C">CJ Hartley</name></author><author><name sortKey="Tiller, L" uniqKey="Tiller L">L Tiller</name></author><author><name sortKey="Rao, L" uniqKey="Rao L">L Rao</name></author><author><name sortKey="Schulz, Dg" uniqKey="Schulz D">DG Schulz</name></author><author><name sortKey="Nagueh, Sf" uniqKey="Nagueh S">SF Nagueh</name></author><author><name sortKey="Zoghbi, Wa" uniqKey="Zoghbi W">WA Zoghbi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Butz, T" uniqKey="Butz T">T Butz</name></author><author><name sortKey="Lang, Cn" uniqKey="Lang C">CN Lang</name></author><author><name sortKey="Van Bracht, M" uniqKey="Van Bracht M">M van Bracht</name></author><author><name sortKey="Prull, Mw" uniqKey="Prull M">MW Prull</name></author><author><name sortKey="Yeni, H" uniqKey="Yeni H">H Yeni</name></author><author><name sortKey="Maagh, P" uniqKey="Maagh P">P Maagh</name></author><author><name sortKey="Plehn, G" uniqKey="Plehn G">G Plehn</name></author><author><name sortKey="Meissner, A" uniqKey="Meissner A">A Meissner</name></author><author><name sortKey="Trappe, Hj" uniqKey="Trappe H">HJ Trappe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pirat, B" uniqKey="Pirat B">B Pirat</name></author><author><name sortKey="Mcculloch, Ml" uniqKey="Mcculloch M">ML McCulloch</name></author><author><name sortKey="Zoghbi, Wa" uniqKey="Zoghbi W">WA Zoghbi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tugcu, A" uniqKey="Tugcu A">A Tugcu</name></author><author><name sortKey="Guzel, D" uniqKey="Guzel D">D Guzel</name></author><author><name sortKey="Yildirimturk, O" uniqKey="Yildirimturk O">O Yildirimturk</name></author><author><name sortKey="Aytekin, S" uniqKey="Aytekin S">S Aytekin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yildirimturk, O" uniqKey="Yildirimturk O">O Yildirimturk</name></author><author><name sortKey="Tayyareci, Y" uniqKey="Tayyareci Y">Y Tayyareci</name></author><author><name sortKey="Aytekin, S" uniqKey="Aytekin S">S Aytekin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Obert, P" uniqKey="Obert P">P Obert</name></author><author><name sortKey="Gueugnon, C" uniqKey="Gueugnon C">C Gueugnon</name></author><author><name sortKey="Nottin, S" uniqKey="Nottin S">S Nottin</name></author><author><name sortKey="Vinet, A" uniqKey="Vinet A">A Vinet</name></author><author><name sortKey="Gayrard, S" uniqKey="Gayrard S">S Gayrard</name></author><author><name sortKey="Rupp, T" uniqKey="Rupp T">T Rupp</name></author><author><name sortKey="Dumoulin, G" uniqKey="Dumoulin G">G Dumoulin</name></author><author><name sortKey="Tordi, N" uniqKey="Tordi N">N Tordi</name></author><author><name sortKey="Mougin, F" uniqKey="Mougin F">F Mougin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teske, Aj" uniqKey="Teske A">AJ Teske</name></author><author><name sortKey="Boeck, Bwd" uniqKey="Boeck B">BWD Boeck</name></author><author><name sortKey="Melman, Pg" uniqKey="Melman P">PG Melman</name></author><author><name sortKey="Sieswerda, Gt" uniqKey="Sieswerda G">GT Sieswerda</name></author><author><name sortKey="Doevendans, Pa" uniqKey="Doevendans P">PA Doevendans</name></author><author><name sortKey="Cramer, Mj" uniqKey="Cramer M">MJ Cramer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ng, Ac" uniqKey="Ng A">AC Ng</name></author><author><name sortKey="Delgado, V" uniqKey="Delgado V">V Delgado</name></author><author><name sortKey="Bertini, M" uniqKey="Bertini M">M Bertini</name></author><author><name sortKey="Van Der Meer, Rw" uniqKey="Van Der Meer R">RW van der Meer</name></author><author><name sortKey="Rijzewijk, Lj" uniqKey="Rijzewijk L">LJ Rijzewijk</name></author><author><name sortKey="Hooi, E" uniqKey="Hooi E">E Hooi</name></author><author><name sortKey="Siebelink, Hm" uniqKey="Siebelink H">HM Siebelink</name></author><author><name sortKey="Smit, Jw" uniqKey="Smit J">JW Smit</name></author><author><name sortKey="Diamant, M" uniqKey="Diamant M">M Diamant</name></author><author><name sortKey="Romijn, Ja" uniqKey="Romijn J">JA Romijn</name></author><author><name sortKey="De Roos, A" uniqKey="De Roos A">A de Roos</name></author><author><name sortKey="Leung, Dy" uniqKey="Leung D">DY Leung</name></author><author><name sortKey="Lamb, Hj" uniqKey="Lamb H">HJ Lamb</name></author><author><name sortKey="Bax, Jj" uniqKey="Bax J">JJ Bax</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Dj" uniqKey="Chen D">DJ Chen</name></author><author><name sortKey="Cao, Dt" uniqKey="Cao D">DT Cao</name></author><author><name sortKey="Duan, Dy" uniqKey="Duan D">DY Duan</name></author><author><name sortKey="Yuan, Dl" uniqKey="Yuan D">DL Yuan</name></author><author><name sortKey="Yang, Dy" uniqKey="Yang D">DY Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shimabukuro, M" uniqKey="Shimabukuro M">M Shimabukuro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van De Voorde, J" uniqKey="Van De Voorde J">J Van de Voorde</name></author><author><name sortKey="Pauwels, B" uniqKey="Pauwels B">B Pauwels</name></author><author><name sortKey="Boydens, C" uniqKey="Boydens C">C Boydens</name></author><author><name sortKey="Decaluwe, K" uniqKey="Decaluwe K">K Decaluwé</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romeo, Gr" uniqKey="Romeo G">GR Romeo</name></author><author><name sortKey="Lee, J" uniqKey="Lee J">J Lee</name></author><author><name sortKey="Shoelson, Se" uniqKey="Shoelson S">SE Shoelson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nyman, K" uniqKey="Nyman K">K Nyman</name></author><author><name sortKey="Graner, M" uniqKey="Graner M">M Graner</name></author><author><name sortKey="Pentikainen, Mo" uniqKey="Pentikainen M">MO Pentikainen</name></author><author><name sortKey="Lundbom, J" uniqKey="Lundbom J">J Lundbom</name></author><author><name sortKey="Hakkarainen, A" uniqKey="Hakkarainen A">A Hakkarainen</name></author><author><name sortKey="Siren Nieminen, Ms" uniqKey="Siren Nieminen M">MS Sirén Nieminen</name></author><author><name sortKey="Taskinen, Mr" uniqKey="Taskinen M">MR Taskinen</name></author><author><name sortKey="Lundbom, N" uniqKey="Lundbom N">N Lundbom</name></author><author><name sortKey="Lauerma, K" uniqKey="Lauerma K">K Lauerma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, He" uniqKey="Park H">HE Park</name></author><author><name sortKey="Choi, S Y" uniqKey="Choi S">S-Y Choi</name></author><author><name sortKey="Kim, M" uniqKey="Kim M">M Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guzzardi, Ma" uniqKey="Guzzardi M">MA Guzzardi</name></author><author><name sortKey="Iozzo, P" uniqKey="Iozzo P">P Iozzo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mathieu, P" uniqKey="Mathieu P">P Mathieu</name></author><author><name sortKey="Poirier, P" uniqKey="Poirier P">P Poirier</name></author><author><name sortKey="Pibarot, P" uniqKey="Pibarot P">P Pibarot</name></author><author><name sortKey="Lemieux, I" uniqKey="Lemieux I">I Lemieux</name></author><author><name sortKey="Despres, J P" uniqKey="Despres J">J-P Després</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harhay, Mo" uniqKey="Harhay M">MO Harhay</name></author><author><name sortKey="Tracy, Rp" uniqKey="Tracy R">RP Tracy</name></author><author><name sortKey="Bagiella, E" uniqKey="Bagiella E">E Bagiella</name></author><author><name sortKey="Barr, Rg" uniqKey="Barr R">RG Barr</name></author><author><name sortKey="Pinder, D" uniqKey="Pinder D">D Pinder</name></author><author><name sortKey="Hundley, Wg" uniqKey="Hundley W">WG Hundley</name></author><author><name sortKey="Bluemke, Da" uniqKey="Bluemke D">DA Bluemke</name></author><author><name sortKey="Kronmal, Ra" uniqKey="Kronmal R">RA Kronmal</name></author><author><name sortKey="Lima, Ja" uniqKey="Lima J">JA Lima</name></author><author><name sortKey="Kawut, Sm" uniqKey="Kawut S">SM Kawut</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Santamore, Wp" uniqKey="Santamore W">WP Santamore</name></author><author><name sortKey="Dell Talia, Lj" uniqKey="Dell Talia L">LJ Dell’Italia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Varli, M" uniqKey="Varli M">M Varli</name></author><author><name sortKey="Turhan, S" uniqKey="Turhan S">S Turhan</name></author><author><name sortKey="Aras, S" uniqKey="Aras S">S Aras</name></author><author><name sortKey="Atli, T" uniqKey="Atli T">T Atli</name></author><author><name sortKey="Erdogan, G" uniqKey="Erdogan G">G Erdogan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lima Martinez, Mm" uniqKey="Lima Martinez M">MM Lima-Martínez</name></author><author><name sortKey="Blandenier, C" uniqKey="Blandenier C">C Blandenier</name></author><author><name sortKey="Iacobellis, G" uniqKey="Iacobellis G">G Iacobellis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iacobellis, G" uniqKey="Iacobellis G">G Iacobellis</name></author><author><name sortKey="Ribaudo, Mc" uniqKey="Ribaudo M">MC Ribaudo</name></author><author><name sortKey="Assael, F" uniqKey="Assael F">F Assael</name></author><author><name sortKey="Vecci, E" uniqKey="Vecci E">E Vecci</name></author><author><name sortKey="Tiberti, C" uniqKey="Tiberti C">C Tiberti</name></author><author><name sortKey="Zappaterreno, A" uniqKey="Zappaterreno A">A Zappaterreno</name></author><author><name sortKey="Di Mario, U" uniqKey="Di Mario U">U Di Mario</name></author><author><name sortKey="Leonetti, F" uniqKey="Leonetti F">F Leonetti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iacobellis, G" uniqKey="Iacobellis G">G Iacobellis</name></author><author><name sortKey="Singh, N" uniqKey="Singh N">N Singh</name></author><author><name sortKey="Wharton, S" uniqKey="Wharton S">S Wharton</name></author><author><name sortKey="Sharma, Am" uniqKey="Sharma A">AM Sharma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ventetuolo, Ce" uniqKey="Ventetuolo C">CE Ventetuolo</name></author><author><name sortKey="Lima, Ja" uniqKey="Lima J">JA Lima</name></author><author><name sortKey="Barr, Rg" uniqKey="Barr R">RG Barr</name></author><author><name sortKey="Bristow, Mr" uniqKey="Bristow M">MR Bristow</name></author><author><name sortKey="Bagiella, E" uniqKey="Bagiella E">E Bagiella</name></author><author><name sortKey="Chahal, H" uniqKey="Chahal H">H Chahal</name></author><author><name sortKey="Kizer, Jr" uniqKey="Kizer J">JR Kizer</name></author><author><name sortKey="Lederer, Dj" uniqKey="Lederer D">DJ Lederer</name></author><author><name sortKey="Bluemke, Da" uniqKey="Bluemke D">DA Bluemke</name></author><author><name sortKey="Kawut, Sm" uniqKey="Kawut S">SM Kawut</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gregori, M" uniqKey="Gregori M">M Gregori</name></author><author><name sortKey="Tocci, G" uniqKey="Tocci G">G Tocci</name></author><author><name sortKey="Marra, A" uniqKey="Marra A">A Marra</name></author><author><name sortKey="Pignatelli, G" uniqKey="Pignatelli G">G Pignatelli</name></author><author><name sortKey="Santolamazza, C" uniqKey="Santolamazza C">C Santolamazza</name></author><author><name sortKey="Befani, A" uniqKey="Befani A">A Befani</name></author><author><name sortKey="Ciavarella, Gm" uniqKey="Ciavarella G">GM Ciavarella</name></author><author><name sortKey="Ferrucci, A" uniqKey="Ferrucci A">A Ferrucci</name></author><author><name sortKey="Paneni, F" uniqKey="Paneni F">F Paneni</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Auvergne (région administrative)</li><li>Auvergne-Rhône-Alpes</li><li>Provence-Alpes-Côte d'Azur</li><li>Victoria (État)</li></region><settlement><li>Avignon</li><li>Clermont-Ferrand</li><li>Melbourne</li></settlement></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Serrano Ferrer, Juan" sort="Serrano Ferrer, Juan" uniqKey="Serrano Ferrer J" first="Juan" last="Serrano-Ferrer">Juan Serrano-Ferrer</name></region><name sortKey="Chapier, Robert" sort="Chapier, Robert" uniqKey="Chapier R" first="Robert" last="Chapier">Robert Chapier</name><name sortKey="Courteix, Daniel" sort="Courteix, Daniel" uniqKey="Courteix D" first="Daniel" last="Courteix">Daniel Courteix</name><name sortKey="Crendal, Edward" sort="Crendal, Edward" uniqKey="Crendal E" first="Edward" last="Crendal">Edward Crendal</name><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Frédéric" last="Dutheil">Frédéric Dutheil</name><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Frédéric" last="Dutheil">Frédéric Dutheil</name><name sortKey="Lesourd, Bruno" sort="Lesourd, Bruno" uniqKey="Lesourd B" first="Bruno" last="Lesourd">Bruno Lesourd</name><name sortKey="Lesourd, Bruno" sort="Lesourd, Bruno" uniqKey="Lesourd B" first="Bruno" last="Lesourd">Bruno Lesourd</name><name sortKey="Obert, Philippe" sort="Obert, Philippe" uniqKey="Obert P" first="Philippe" last="Obert">Philippe Obert</name><name sortKey="Vinet, Agnes" sort="Vinet, Agnes" uniqKey="Vinet A" first="Agnès" last="Vinet">Agnès Vinet</name><name sortKey="Walther, Guillaume" sort="Walther, Guillaume" uniqKey="Walther G" first="Guillaume" last="Walther">Guillaume Walther</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Walther, Guillaume" sort="Walther, Guillaume" uniqKey="Walther G" first="Guillaume" last="Walther">Guillaume Walther</name></region><name sortKey="Courteix, Daniel" sort="Courteix, Daniel" uniqKey="Courteix D" first="Daniel" last="Courteix">Daniel Courteix</name><name sortKey="Crendal, Edward" sort="Crendal, Edward" uniqKey="Crendal E" first="Edward" last="Crendal">Edward Crendal</name><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Frédéric" last="Dutheil">Frédéric Dutheil</name><name sortKey="Naughton, Geraldine" sort="Naughton, Geraldine" uniqKey="Naughton G" first="Geraldine" last="Naughton">Geraldine Naughton</name><name sortKey="Obert, Philippe" sort="Obert, Philippe" uniqKey="Obert P" first="Philippe" last="Obert">Philippe Obert</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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